Two middle-aged running brothers – a barefoot Tarahumara wannabe and a used-shoe salesman – attempt to conquer the marathon, the world of commerce and each other, and kick-start their lives, all from their Mom’s basement. Throw in ample support from Myles’ science nerd girlfriend, a cagey motivational speaker on the ropes and an asset-laden blond bombshell, and it’s looking like an uphill battle.